Bio of Nadia Amrani, Ph.D.

By admin • May 18th, 2010

Dr. Nadia Amrani is a native of Marrakech (Morocco), where she attended The University of Sciences Cadi Ayad and obtained her Bachelor Degree with distinction in Biology in 1990. She moved then to Toulouse (France) to pursue her undergraduate studies at the Ecole Nationale Supérieure Agronomique de Toulouse where she obtained her first Master Degree in Plant Biotechnology in 1991. In 1992, Dr. Amrani obtained her second Master Degree (DEA) from the same institution where she published two of her first scientific research papers. Her main project was to develop assays to regenerate and produce haploid plants in crosses between tetraploid and hexaploid wheat and maize. Dr. Amrani started her doctorate work in the Department of Molecular Genetics at the Centre National de la Recherche Scientifique (CNRS) at Gif-Sur-Yvette (France), in affiliation with the University of Pierre et Marie-Curie, Paris. During her graduate studies in France, she applied for and won different fellowships from A.R.C. (Association pour la Recherche contre le Cancer, 1996-1997), from the CNRS (1994-1997), and from the government of Morocco (1991-1997). In 1997 she obtained her PhD with the highest award and published three scientific papers. Prior to moving to the United States, she obtained a fellowship from Human Frontier Science Program (1998-2000) and started her postdoctoral training in the Department of Molecular Genetics and Microbiology at The University of Massachusetts (Worcester, US) where she holds currently a position of Research Assistant Professor. Dr. Amrani’s most recent work was published in the prestigious scientific journal Nature, where she describes a new model of the closed loop mRNP structure which forms during translation initiation in eukaryotes. Dr. Amrani won Biomatec’s 2008 Award as a recognition for her excellent scientific contribution and for her active participation in the organization of the 2008 Biomatec Annual Meeting. Dr. Amrani is married to Dr. Mustapha Abdelouahed, they both live with their three daughters, Sara, Weaam and Rania, in Worcester, Massachusetts (US). She became a naturalized United States citizen in 2008. The most recent of Dr. Amrani’s publications are:

• Amrani, N., Ghosh, S., Mangus, D.A., and Jacobson, A. Translation factors promote formation of two states of the closed loop mRNP. Nature, 453: 1276-1280, 2008.
• He, F., Amrani, N., Johansson, M.J.O., and Jacobson, A. Qualitative and quantitative assessment of the activity of the yeast NMD pathway. In: Methods in Enzymology Vol. 449. RNA Turnover (Editors: L. Maquat and M. Kiledjian), Elsevier, San Diego, pp. 127-148, 2008.
• Wu, C., Amrani, N., Jacobson, A. and Sachs, M. S. The use of fungal in vitro systems for studying translational regulation. In: Methods in Enzymology Vol. 429. Translation Initiation: Extract Systems and Molecular Genetics (Editor: J. Lorsch), Elsevier, San Diego, pp. 203-225, 2007.
• Amrani, N. and Jacobson, A. All termination events are not equal: premature termination in yeast is aberrant and triggers NMD. In: Nonsense-mediated mRNA decay (Editor: L.E. Maquat), Landes Bioscience, Texas, pp. 15-25, 2006.
• Amrani, N., Sachs, M. S. and Jacobson, A. Early nonsense: mRNA decay solves a translational problem. Nat Rev Mol Cell Biol, 7: 415-425, 2006.
• Amrani, N., Dong, s., He, F., Ganesan, R., Ghosh, S., Kervestin, S., Li, C., Mangus, D. A., Spatrick, P. and Jacobson, A. Aberrant termination triggers nonsense-mediated mRNA decay. Biochem Soc Trans, 34: 39-42, 2006.
• Amrani, N., Ganesan, R., Kervestin, S., Mangus, D. A., Ghosh, S. and Jacobson, A. A faux 3′-UTR promotes aberrant termination and triggers nonsense-mediated mRNA decay. Nature, 432: 112-118, 2004.
• Kervestin, S., and Amrani, N. Translational regulation of gene expression. Genome Biol., 5 (12): 359-1.3, 2004.

 

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